Ep-PAINE-nym



Heinz Bodies

 

Other Known AliasesHeinz-Ehrlich Bodies, Ehrlich Inner Body

DefinitionDeep purple small irregular bodies in red cells stained with crystal violet which represents denatured hemoglobin due to oxidative damage.

Image result for heinz bodies

Clinical SignificanceSeen in conditions in with high oxidative stress such as:

  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency
  • Alpha thalassemia
  • NADPH deficiency
  • Chronic liver disease
  • Asplenia

History – Given to Dr. Robert Heinz (1865-1924), who was a German physician and pharmacologist who first reported these findings 1890 in the blood of guinea pigs that had treated with acetylphenylhydrazine.  Dr. Paul Ehrlich (1854-1915), was a German bacteriologist and immunologist, is also credited with this, but did not publish it formally (as best I can tell)


References

  1. Firkin BG and Whitwirth JA.  Dictionary of Medical Eponyms. 2nd ed.  New York, NY; Parthenon Publishing Group. 1996.
  2. Yee AJ, Pfiffner P. (2012).  Medical Eponyms (Version 1.4.2) [Mobile Application Software].  Retrieved http://itunes.apple.com
  3. R. Heinz. Morphologische Veränderungen des roten Blutkörperchens durch Gifte. [Virchows] Archiv für pathologische Anatomie und Physiologie und für klinische Medizin, Berlin, 1890, 122: 112-116

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