PAINE Podcast and Medical Blog

#35 – Peptic Ulcer Disease

Wrinkled Parchment Paper



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Definitions


Epidemiology


Etiologies

There are numerous causes of PUD and include infections, stress, medications, alcohol, cirrhosis, neoplasms, etc.  The two main causes in developed countries are:



Clinical Manifestations


Complications


Red Flags


Work-up


Initial Management


References

  1. Sung JJ, Kuipers EJ, El-Serag HB. Systematic review: the global incidence and prevalence of peptic ulcer disease. Alimentary pharmacology & therapeutics. 2009; 29(9):938-46. [pubmed]
  2. Lin KJ, García Rodríguez LA, Hernández-Díaz S. Systematic review of peptic ulcer disease incidence rates: do studies without validation provide reliable estimates? Pharmacoepidemiology and drug safety. 2011; 20(7):718-28. [pubmed]
  3. Sonnenberg A. Temporal trends and geographical variations of peptic ulcer disease. Alimentary pharmacology & therapeutics. 1995; 9 Suppl 2:3-12. [pubmed]
  4. Thorat MA, Cuzick J. Prophylactic use of aspirin: systematic review of harms and approaches to mitigation in the general population. European journal of epidemiology. 2015; 30(1):5-18. [pubmed]
  5. García Rodríguez LA, Hernández-Díaz S. Risk of uncomplicated peptic ulcer among users of aspirin and nonaspirin nonsteroidal antiinflammatory drugs. American journal of epidemiology. 2004; 159(1):23-31. [pubmed]
  6. Gururatsakul M, Holloway RH, Talley NJ, Holtmann GJ. Association between clinical manifestations of complicated and uncomplicated peptic ulcer and visceral sensory dysfunction. Journal of gastroenterology and hepatology. 2010; 25(6):1162-9. [pubmed]
  7. Wilcox CM, Clark WS. Features associated with painless peptic ulcer bleeding. The American journal of gastroenterology. 1997; 92(8):1289-92. [pubmed]
  8. Paimela H, Paimela L, Myllykangas-Luosujärvi R, Kivilaakso E. Current features of peptic ulcer disease in Finland: incidence of surgery, hospital admissions and mortality for the disease during the past twenty-five years. Scandinavian journal of gastroenterology. 2002; 37(4):399-403. [pubmed]
  9. Malfertheiner P, Megraud F, O’Morain CA. Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report. Gut. 2017; 66(1):6-30. [pubmed]
  10. Chiorean MV, Locke GR, Zinsmeister AR, Schleck CD, Melton LJ. Changing rates of Helicobacter pylori testing and treatment in patients with peptic ulcer disease. The American journal of gastroenterology. 2002; 97(12):3015-22. [pubmed]
  11. Yeomans ND, Tulassay Z, Juhász L. A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. Acid Suppression Trial: Ranitidine versus Omeprazole for NSAID-associated Ulcer Treatment (ASTRONAUT) Study Group. The New England journal of medicine. 1998; 338(11):719-26. [pubmed]
  12. Duck WM, Sobel J, Pruckler JM. Antimicrobial resistance incidence and risk factors among Helicobacter pylori-infected persons, United States. Emerging infectious diseases. 2004; 10(6):1088-94. [pubmed]
  13. Chey WD, Leontiadis GI, Howden CW, Moss SF. ACG Clinical Guideline: Treatment of Helicobacter pylori Infection. The American journal of gastroenterology. 2017; 112(2):212-239. [pubmed]