What are the indications for high-intensity statin therapy for hyperlipidemia?
New joint guidelines were released in 2013 by ACC/AHA on the management of hyperlipidemia. In these guidelines, there are 3 criteria for high intensity statin therapy:
- Age < 75 years with a clinical Atherosclerotic Cardiovascular Disease (ASCVD):
- Acute coronary syndrome
- Myocardial infarction
- Stable or unstable angina
- Revascularization procedures
- Cerebrovascular disease
- Peripheral arterial disease
- LDL ≥ 190 mg/dL
- Age 40-75 years, with diabetes, LDL 70-189 mg/dL, and 10-year ASCVD risk > 7.5%
What are the drugs and dosing for high-intensity statin therapy?
There are only 2 medications that have been studied that are recommended for high-intensity statin therapy:
- Atorvastatin 40-80mg daily
- Rosuvastatin 20-40mg daily
Stone NJ, Robinson JG, Lichtenstein AH. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Journal of the American College of Cardiology. 63(25 Pt B):2889-934. 2014. [pubmed]