- What are these two conditions called?
- Which is associated with other genetic conditions?
- Which has better associated outcomes?
- The condition on the left is an omphalocele and on the right is a gastroschisis.
- Omphalocele is a midline abdominal wall defect where the contents are covered by a membrane of amnion and peritoneum. It occurs at the base of umbilical cord.
- Gastroschisis (more common) is a full-thickness, paraumbilical abdominal wall defect with free-evisceration of abdominal contents
- The majority of infants with an omphalocele have associated congenital anomalies including Beckwith-Wiedemann syndrome, Trisomy 13 and 18, and numerous other subsystem involvement. Gastroschisis generally has no other abnormalities, but can have associated intestinal atresia in up to 10%
- Gastroschisis has statistically better overall outcomes since it is not associated with any other genetic conditions.
- Carlo WA. The Umbilicus. In: Nelson Textbook of Pediatrics. 20th ed. 2016. Chapter 105: 890-891.
- Abdominal Wall Defect. Genetics Home Reference. https://ghr.nlm.nih.gov/condition/abdominal-wall-defect