PAINE #PANCE Pearl – Gastrointestinal/Nutritional


What vitamins have a higher potential for causing toxicity and why?


Fat soluble vitamins can be stored in the adipose tissue instead of excreted if in excess.  As a result, vitamins A, D, E, and K can cause toxicity if patients take too much (in this order of incidence as well).

  • Hypervitamintosis A can result in ataxia, hepatotoxicity, visual impairments, and orange skin.
  • Hypervitamintosis D can result in hyperphosphatemia and hypercalcemia.
  • Hypervitamintosis E can block vitamin K absorption and leads to easy bleeding and bruising
  • Hypervitamintosis K is very rare and really only seen in infants receiving newborn injections after birth.


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