Kahler’s Disease


Other Known AliasesMacIntyre Syndrome

DefinitionMultiple Myeloma

Clinical Significance None

History – Given to Dr. Otto Kahler (1849-1893), who was a Austrian physician and Professor of Medicine at the German University in Prague.  Although he is the namesake for this condition, William MacIntyre (1791-1857) first described multiple myeloma in 1850.


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  2. Bartolucci S, Forbis P.  Stedman’s Medical Eponyms.  2nd ed.  Baltimore, MD; LWW.  2005.
  3. Yee AJ, Pfiffner P. (2012).  Medical Eponyms (Version 1.4.2) [Mobile Application Software].  Retrieved http://itunes.apple.com.
  4. Whonamedit – dictionary of medical eponyms. http://www.whonamedit.com/. Accessed March 7, 2017.
  5. Kahler O.  Zur Symptomatologie des multiplen Myeloms. Beobachtung von Albumosurie. Prager medicinische Wochenshrift, Prague, 1889, 14: 33-35, 44-49.
  6. Macintyre W. Case of Mollities and Fragilitas Ossium, accompanied with urine strongly charged with animal matter. Medico-chirurgical transactions. 33:211-32. 1850. [pubmed]
  7. Kyle RA, Rajkumar SV. Multiple myeloma. Blood. 2008;111(6):2962-2972 [pubmed]

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