Other Known Aliases – none
Definition – chronic, irreversible amnestic disorder caused by thiamine deficiency classically associated with longstanding alcohol use
Clinical Significance – there are seven major symptoms of Korsakoff syndrome that can be seen clinically:
- Anterograde amnesia
- Retrograde amnesia
- Amnesia of fixation
- Minimal content in conversation
- Lack of insight
This is classically taught as a continuation of Wernicke’s encephalopathy, though patients may not present in early stages.
History – Named after Sergei Sergeievich Korsakoff (1854-1900), who was a Russian neuropsychiatrist and received his medical doctorate from Moscow State University in 1875. He would go on to gain fame in fields of neurology and psychiatry culminating in his appointment as professor extraordinarius at a dedicated psychiatric hospital in Moscow and helping to found the Moscow Society of Neuropathologists and Psychiatrists. His eponymous condition was first described in 1887 in his graduate thesis entitled “Alcoholic Paralysis”
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