Definition – Blue discoloration of the cervix and vaginal mucosa seen in early pregnancy.
Clinical Significance – Due to increased blood flow to support a newly implanted embryo and can be seen 6-8 weeks after conception.
History – Given to James R. Chadwick, an American gynecologist of the late 19th century, after he read a paper before the American Gynecologic Society in 1886, but 1st described by Etienne Jacquemin in 1836. Dr. Chadwick did give appropriate recognition to Dr. Jacquemin during this presentation.
- Firkin BG and Whitwirth JA. Dictionary of Medical Eponyms. 2nd ed. New York, NY; Parthenon Publishing Group. 1996.
Gleichert JE. Etienne Joseph Jacquemin, discoverer of ‘Chadwick’s sign’. Journal of the history of medicine and allied sciences. 1971;26(1):75-80. [pubmed]