Zollinger-Ellison Syndrome

Other Known Aliases – Strøm-Zollinger-Ellison Syndrome

Definition – hypersecretory condition of the stomach caused by a gastrinoma

Clinical Significance – Signs of symptoms of ZES include chronic diarrhea, steatorrhea, GERD, nausea, hematemesis, malabsorption, weight loss, and abdominal pain. This syndrome should be considered in any patient with refractory GERD or PUD. Diagnosis is confirmed with elevated fasting gastrin levels.

History – Named after Robert Milton Zollinger (1903-1992) and Edwin Homer Ellison (1918-1970), who were both American general surgeons and both received their medical doctorates from Ohio State University in 1927 and 1940 respectively. Zollinger would go on to serve in mobile surgical teams during World War II in France and received the Legion of Merit Award and Battle Stars for his contributions. After the war, he would become chairman of the department of surgery at Ohio State in 1947, whee he would spend the majority of career. Ellison would distinguish himself in the realm of research and his career would culminate as chairman of surgery at Marquette School of Medicine in 1967. In 1955, they would present their postulation that hypersecretion of the stomach acid could be due to tumors at the American Surgical Association meeting in Philadelphia and would publish their findings later that year. It should be noted that Roar Strøm, a Norwegian physician, published his findings of this condition in 1952.

References

1. Firkin BG and Whitwirth JA.  Dictionary of Medical Eponyms. 2nd ed.  New York, NY; Parthenon Publishing Group. 1996.
2. Bartolucci S, Forbis P.  Stedman’s Medical Eponyms.  2nd ed.  Baltimore, MD; LWW.  2005.
3. Yee AJ, Pfiffner P. (2012).  Medical Eponyms (Version 1.4.2) [Mobile Application Software].  Retrieved http://itunes.apple.com.
4. Whonamedit – dictionary of medical eponyms. http://www.whonamedit.com
5. Up To Date. www.uptodate.com
6. R. Strøm: A case of peptic ulcer and insuloma. Acta Chirurgica Scandinavica, Stockholm, 1952-1953, 104: 252-260.
7. R. M. Zollinger, E. H. Ellison. Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas. Annals of Surgery, Philadelphia, 1955, 142: 709-728.

Castell’s Point

Other Known Aliases – none

Definition – percussion point on the lowest intercostal space (usually 8th or 9th) in the left anterior axillary line

Clinical Significance – This point is an alternative maneuver to clinically determine if a patient has splenomegaly. With the patient in the supine position, have the patient fully expire and begin percussing in this point while the patient fully inspires. At full expiration, resonance should be appreciated from either the splenic flexure of the colon or gas in the stomach. During inspiration, the spleen moves inferiorly and, if enlarged, will enter this point. This will change the percussion from resonance to dullness.

History – Named after Donald Castell (1935-2021), an American gastroenterologist who received his medical doctorate from George Washington University in 1960. He would spend the majority of his career in the Navy culminating in chair of the Department of Medicine at the National Naval Medical Center in Bethesda, MD. He also held numerous leadership positions national in the American Gastroenterology Association and had a prolific career in scholarship and research. It was through this passion for research that he published his eponymous finding in 1967 while stationed in the Great Lakes naval base in Illinois.

References

1. Firkin BG and Whitwirth JA.  Dictionary of Medical Eponyms. 2nd ed.  New York, NY; Parthenon Publishing Group. 1996.
2. Bartolucci S, Forbis P.  Stedman’s Medical Eponyms.  2nd ed.  Baltimore, MD; LWW.  2005.
3. Yee AJ, Pfiffner P. (2012).  Medical Eponyms (Version 1.4.2) [Mobile Application Software].  Retrieved http://itunes.apple.com.
4. Whonamedit – dictionary of medical eponyms. http://www.whonamedit.com
5. Up To Date. www.uptodate.com
6. Castell DO. The spleen percussion sign. A useful diagnostic technique. Ann Intern Med. 1967; 67(6):1265-7. [pubmed]
7. https://medicine.musc.edu/departments/dom/news-and-awards/2021/january-2021/remembering-don-castell